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. 2021 Dec 3;9:689067. doi: 10.3389/fcell.2021.689067

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Copyright © 2021 Zhang, Liang, Wu, Pei, Guo, Chu, Ding, Bao, Kalwar and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The alteration of global m⁶A modification in adipocyte compared with preadipocyte. (A) Volcano plots showing different m⁶A peaks (fold change ≥2 and p < 0.05) between preadipocyte and adipocyte. (B) GO terms of genes with differential m⁶A peaks between preadipocyte and adipocyte. (C) The top 20 markedly enriched pathways for the genes of differential peaks between preadipocyte and adipocyte. (D) The abundance of m⁶A on KLF9, FOXO1, and UHRF1mRNA transcripts observed by m⁶A-seq in preadipocyte and adipocyte. Blue boxes represent exons; blue lines represent introns.