Comparison 1. Typical antipsychotics versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Agitation	4	361	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.36 [‐0.57, ‐0.15]
1.2 Psychosis	2	240	Std. Mean Difference (IV, Fixed, 95% CI)	‐0.29 [‐0.55, ‐0.03]
1.3 Somnolence	3	466	Risk Ratio (IV, Fixed, 95% CI)	2.62 [1.51, 4.56]
1.4 Somnolence (RD)	3	466	Risk Difference (IV, Fixed, 95% CI)	0.12 [0.06, 0.18]
1.5 Extrapyramidal symptoms	3	467	Risk Ratio (IV, Fixed, 95% CI)	2.26 [1.58, 3.23]
1.6 Extrapyramidal symptoms (RD)	3	467	Risk Difference (IV, Fixed, 95% CI)	0.19 [0.11, 0.27]
1.7 Any serious adverse events	1	193	Risk Ratio (IV, Fixed, 95% CI)	1.32 [0.65, 2.66]
1.8 Any serious adverse events (RD)	1	193	Risk Difference (IV, Fixed, 95% CI)	0.04 [‐0.06, 0.14]
1.9 Death	6	578	Risk Ratio (IV, Fixed, 95% CI)	1.46 [0.54, 4.00]
1.10 Death (RD)	6	578	Risk Difference (IV, Fixed, 95% CI)	0.01 [‐0.02, 0.03]
1.11 Number of responders for agitation	4	367	Risk Ratio (IV, Fixed, 95% CI)	1.18 [1.01, 1.38]
1.12 Number of responders for agitation (RD)	4	367	Risk Difference (IV, Fixed, 95% CI)	0.13 [0.04, 0.22]
1.13 Number of responders for psychosis	2	259	Risk Ratio (IV, Fixed, 95% CI)	1.31 [0.90, 1.92]
1.14 Number of responders for psychosis (RD)	2	259	Risk Difference (IV, Fixed, 95% CI)	0.09 [‐0.03, 0.20]
1.15 Discontinuation due to adverse events	4	442	Risk Ratio (IV, Fixed, 95% CI)	1.70 [1.02, 2.82]
1.16 Discontinuation due to adverse events (RD)	4	442	Risk Difference (IV, Fixed, 95% CI)	0.06 [0.00, 0.12]
1.17 Discontinuation (any reason)	6	578	Risk Ratio (IV, Fixed, 95% CI)	1.16 [0.89, 1.51]
1.18 Discontinuation (any reason) (RD)	6	578	Risk Difference (IV, Fixed, 95% CI)	0.01 [‐0.06, 0.07]
1.19 Functioning (ADL)	2	249	Std. Mean Difference (IV, Fixed, 95% CI)	0.38 [0.13, 0.63]
1.20 Cognitive function	2	205	Mean Difference (IV, Fixed, 95% CI)	‐0.25 [‐1.27, 0.77]
1.21 Carer burden	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected