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. 2021 Dec 17;2021(12):CD013304. doi: 10.1002/14651858.CD013304.pub2

Comparison 2. Haloperidol versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
2.1 Agitation 3 330 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.29 [‐0.51, ‐0.07]
2.2 Psychosis 2 240 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.29 [‐0.55, ‐0.03]
2.3 Somnolence 3 466 Risk Ratio (IV, Fixed, 95% CI) 2.62 [1.51, 4.56]
2.4 Extrapyramidal symptoms 1   Risk Ratio (IV, Fixed, 95% CI) Totals not selected
2.5 Serious adverse events 1   Risk Ratio (IV, Fixed, 95% CI) Totals not selected
2.6 Death 5 545 Risk Ratio (IV, Fixed, 95% CI) 1.88 [0.65, 5.48]
2.7 Number of responders for agitation 3 334 Risk Ratio (IV, Fixed, 95% CI) 1.15 [0.99, 1.35]
2.8 Number of responders for psychosis 2 259 Risk Ratio (IV, Fixed, 95% CI) 1.31 [0.90, 1.92]
2.9 Discontinuation due to adverse events 3 409 Risk Ratio (IV, Fixed, 95% CI) 1.81 [1.08, 3.03]
2.10 Discontinuation (any reason) 5 545 Risk Ratio (IV, Fixed, 95% CI) 1.18 [0.90, 1.54]
2.11 Functioning (ADL) 2 249 Std. Mean Difference (IV, Fixed, 95% CI) 0.38 [0.13, 0.63]
2.12 Cognitive function 2 205 Mean Difference (IV, Fixed, 95% CI) ‐0.25 [‐1.27, 0.77]
2.13 Carer burden 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected