| 3.1 Agitation |
7 |
1971 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.21 [‐0.30, ‐0.12] |
| 3.1.1 Patients with agitation
|
6 |
1670 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.18 [‐0.28, ‐0.08] |
| 3.1.2 Patients with aggression
|
1 |
301 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.38 [‐0.61, ‐0.15] |
| 3.2 Psychosis |
12 |
3364 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.11 [‐0.18, ‐0.03] |
| 3.3 Somnolence |
13 |
3878 |
Risk Ratio (IV, Fixed, 95% CI) |
1.93 [1.57, 2.39] |
| 3.4 Somnolence (RD) |
13 |
3878 |
Risk Difference (IV, Fixed, 95% CI) |
0.07 [0.05, 0.08] |
| 3.5 Extrapyramidal symptoms |
15 |
4180 |
Risk Ratio (IV, Fixed, 95% CI) |
1.39 [1.14, 1.68] |
| 3.6 Extrapyramidal symptoms (RD) |
15 |
4180 |
Risk Difference (IV, Fixed, 95% CI) |
0.03 [0.02, 0.05] |
| 3.7 Any adverse event |
11 |
2785 |
Risk Ratio (IV, Fixed, 95% CI) |
1.05 [1.02, 1.09] |
| 3.8 Any adverse event (RD) |
11 |
2785 |
Risk Difference (IV, Fixed, 95% CI) |
0.05 [0.02, 0.07] |
| 3.9 Any serious adverse event |
15 |
4316 |
Risk Ratio (IV, Fixed, 95% CI) |
1.32 [1.09, 1.61] |
| 3.10 Any serious adverse event (RD) |
15 |
4316 |
Risk Difference (IV, Fixed, 95% CI) |
0.04 [0.02, 0.05] |
| 3.11 Death |
17 |
5032 |
Risk Ratio (IV, Fixed, 95% CI) |
1.36 [0.90, 2.05] |
| 3.12 Death (RD) |
17 |
5032 |
Risk Difference (IV, Fixed, 95% CI) |
0.01 [‐0.00, 0.02] |
| 3.13 Number of responders for agitation |
4 |
1304 |
Risk Ratio (IV, Fixed, 95% CI) |
1.31 [1.16, 1.48] |
| 3.13.1 Assessments not including physical aggression |
3 |
959 |
Risk Ratio (IV, Fixed, 95% CI) |
1.22 [1.07, 1.40] |
| 3.13.2 Assessments including physical aggression |
1 |
345 |
Risk Ratio (IV, Fixed, 95% CI) |
1.69 [1.31, 2.17] |
| 3.14 Number of responders for agitation (RD) |
4 |
1304 |
Risk Difference (IV, Fixed, 95% CI) |
0.13 [0.08, 0.18] |
| 3.14.1 Assessments not including physical aggression |
3 |
959 |
Risk Difference (IV, Fixed, 95% CI) |
0.10 [0.04, 0.16] |
| 3.14.2 Assessments including physical aggression |
1 |
345 |
Risk Difference (IV, Fixed, 95% CI) |
0.22 [0.12, 0.33] |
| 3.15 Number of responders for psychosis |
7 |
1958 |
Risk Ratio (IV, Fixed, 95% CI) |
1.13 [1.03, 1.23] |
| 3.16 Number of responders for psychosis (RD) |
7 |
1958 |
Risk Difference (IV, Fixed, 95% CI) |
0.08 [0.04, 0.13] |
| 3.17 Discontinuation due to adverse events |
17 |
5058 |
Risk Ratio (IV, Fixed, 95% CI) |
1.41 [1.15, 1.72] |
| 3.18 Discontinuation due to adverse events (RD) |
17 |
5058 |
Risk Difference (IV, Fixed, 95% CI) |
0.04 [0.02, 0.06] |
| 3.19 Discontinuation (any reason) |
18 |
5095 |
Risk Ratio (IV, Fixed, 95% CI) |
0.95 [0.89, 1.01] |
| 3.20 Discontinuation (any reason) (RD) |
18 |
5095 |
Risk Difference (IV, Fixed, 95% CI) |
‐0.00 [‐0.02, 0.02] |
| 3.21 Functioning (ADL) |
3 |
514 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.21 [‐0.39, ‐0.03] |
| 3.22 Cognitive function |
11 |
2698 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.10 [‐0.19, ‐0.02] |
| 3.23 Cognitive function (single study) |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 3.24 Health‐related quality of life |
1 |
151 |
Mean Difference (IV, Fixed, 95% CI) |
0.95 [‐4.14, 6.04] |
| 3.25 Time spend providing care (caregiver) |
1 |
151 |
Mean Difference (IV, Fixed, 95% CI) |
0.08 [‐1.39, 1.55] |
