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. 2021 Dec 17;2021(12):CD013304. doi: 10.1002/14651858.CD013304.pub2

Comparison 5. Quetiapine versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
5.1 Agitation 3 615 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.14 [‐0.31, 0.02]
5.2 Psychosis 2 220 Std. Mean Difference (IV, Fixed, 95% CI) 0.05 [‐0.22, 0.31]
5.3 Somnolence 4 798 Risk Ratio (IV, Fixed, 95% CI) 4.83 [2.73, 8.57]
5.4 Extrapyramidal symptoms 4 799 Risk Ratio (IV, Fixed, 95% CI) 0.94 [0.52, 1.70]
5.5 Any adverse event 3 609 Risk Ratio (IV, Fixed, 95% CI) 1.03 [0.93, 1.14]
5.6 Any serious adverse event 4 799 Risk Ratio (IV, Fixed, 95% CI) 1.32 [0.86, 2.03]
5.7 Death 5 861 Risk Ratio (IV, Fixed, 95% CI) 1.48 [0.67, 3.31]
5.8 Number of responders for agitation 2 569 Risk Ratio (IV, Fixed, 95% CI) 1.35 [1.02, 1.78]
5.9 Number of responders for psychosis 2 230 Risk Ratio (IV, Fixed, 95% CI) 1.03 [0.78, 1.36]
5.10 Discontinuation due to adverse events 5 858 Risk Ratio (IV, Fixed, 95% CI) 1.37 [0.89, 2.11]
5.11 Discontinuation (any reason) 5 861 Risk Ratio (IV, Fixed, 95% CI) 0.97 [0.88, 1.08]
5.12 Functioning (ADL) 2 258 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.17 [‐0.42, 0.07]
5.13 Cognitive function 4 584 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.28, 0.07]
5.14 Cognitive function (single study) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.15 Health‐related quality of life 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.16 Time spend providing care (caregiver) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected