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. 2021 Dec 3;12:711905. doi: 10.3389/fmicb.2021.711905

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Copyright © 2021 Liu, Zeng, Qu, Wang and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential metabolites were significantly enriched in multiple pathways, suggesting that the addition of CE remarkably perturbed gut metabolic activities (n = 6 hens/group). (A) Functional KEGG pathway enrichment analysis of the differential expressed metabolites was carried out through three different platforms (LIPEA, MBRole, and MetaboAnalyst). (B) Analysis of metabolic pathways of DC and CE groups of differentially expressed metabolites was shown by bubble plot, each dot represents a metabolic pathway. X-axis and Y-axis stand for pathway impact and −log₁₀(P-value), respectively.