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. 2021 Dec 3;12:711905. doi: 10.3389/fmicb.2021.711905

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Copyright © 2021 Liu, Zeng, Qu, Wang and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CE enhanced co-expression correlation among the microbial community and the differential metabolites were tightly associated with the signature microbiota. (A) Microbial community co-expression network analysis explores the relationship between CE and DC groups through three standard algorithms. Different nodes represent different bacterial genera, colors represent phyla, and the dots size represent node degree. (B) A network diagram of differential microbiota-metabolites demonstrates that the up-regulated microbial were closely related with the up-regulated metabolites while down-regulated microbial were closely related with the down-regulated metabolites.