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. 2021 Dec 3;12:711905. doi: 10.3389/fmicb.2021.711905

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Copyright © 2021 Liu, Zeng, Qu, Wang and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis was conducted between the top focus metabolites and the signature microbiota to explore the key factors influencing organismal fitness by adding CE. (A) Heat map of differential metabolites with a bar graph of VIP values from previous OPLS-DA model. Only if the metabolites were a satisfied condition of VIP > 1 were selected for the following association analysis. (B) The correlation of top focus metabolites and the signature microbiota.