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. 2021 Dec 3;12:786680. doi: 10.3389/fimmu.2021.786680

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Copyright © 2021 Ramavath, Gadipudi, Provera, Gigliotti, Boggio, Bozzola, Albano, Dianzani and Sutti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of ICOS and ICOSL by lymphocytes and monocyte-derived macrophages (MoMFs) infiltrating the liver during acute inflammation. Liver inflammation was induced in response to acute hepatocyte injury caused by carbon tetrachloride (CCl₄) in wild-type mice. The expression of ICOS was evaluated by flow cytometry in CD3⁺ T-lymphocytes infiltrating the liver of control (Cont) and CCl₄-treated mice following 24 or 72 hours after challenge with the toxic agent (A). Characterization of ICOS-expressing CD3⁺/CD4⁺ helper and CD3⁺/CD8⁺ cytotoxic T-cells in the liver of mice receiving CCl₄ for 72 hours (B). Flow cytometry analysis of ICOSL expression among CD11b⁺/F4-80⁺ MoMFs (C). The values are expressed as mean ± SD of 3-4 different cell preparations.