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Regulation of acrAB multidrug efflux genes by RamRA in Salmonella. The expression of the multidrug efflux system genes acrAB is controlled by RamA, an activator protein, and RamR, a repressor. The RamR protein represses the ramA gene expression, which codes for the RamA protein, an expression activator in the acrAB drug efflux system genetic operon. The RamR protein recognizes a specific DNA sequence that exists upstream of the ramA gene and binds to it, repressing its expression.
