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The co-crystal structure of the RamR protein with cholic acid (left) and chenodeoxycholic acid (right). The RamR protein is a dimer that binds to two cholic acid (left) or chenodeoxycholic acid (right) molecules. This binding decreases the DNA binding affinity of the RamR protein, which in turn increasing the expression of RamA, thus promoting the expression of the AcrAB drug efflux system.
