Table 4.
Sensitivity, Specificity, PPV, NPV, LR+, and LR− of Serological Markers for Prediction of Toxoplasmic Encephalitis
| Markers | Sensitivity | Specificity | PPV | NPV | LR+ | LR− |
|---|---|---|---|---|---|---|
| MAG1_4.2 | 68 (48~84)a | 84 (68~94) | 76 (59~87) | 78 (66~86) | 4.25 (1.9~9.1) | 0.38 (.2~.7) |
| MAG1_5.2 | 36 (19~56) | 86 (71~95) | 67 (44~84) | 64 (57~71) | 2.57 (1.0~6.9) | 0.74 (.6~1.0) |
| Third tertile of Toxo IgGb | 57 (37~76) | 81 (65~92) | 70 (52~83) | 71 (61~80) | 3.00 (1.4~6.3) | 0.53 (.3~.8) |
| MAG1_4.2 or third tertile of Toxo IgGb | 86 (67~96) | 70 (53~84) | 69 (56~78) | 87 (72~94) | 2.87 (1.7~4.8) | 0.2 (.1~.5) |
| MAG1_5.2 or third tertile of Toxo IgGb | 64 (44~81) | 78 (62~90) | 69 (53~82) | 74 (63~83) | 2.91 (1.5~5.8) | 0.46 (.3~.8) |
| MAG1_4.2 or MAG1_5.2 or third tertile of Toxo IgGb | 89 (72~98) | 68 (50~82) | 68 (56~77) | 89 (74~96) | 2.79 (1.7~4.5) | 0.16 (.05~.5) |
Abbreviations: IgG, immunoglobulin G; LR+, positive likelihood ratio; LR−, negative likelihood ratio; MAG1, matrix antigen 1; NPV, negative predictive value; PPV, positive predictive value; Toxo, Toxoplasma.
aNumber ( ): % (95% confidence interval).
b Toxoplasma IgG between 3.22 and 4.00 optical density (OD) units.