Table 2.
Parameters during the ovarian stimulation in the POSEIDON groups.
| POSEIDON group 1 (n = 151) | POSEIDON group 2 (n = 101) | POSEIDON group 3 (n = 71) | POSEIDON group 4 (n = 105) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GH | Non-GH | p-value | GH | Non-GH | p-value | GH | Non-GH | p-value | GH | Non-GH | p-value | |
| COH protocol | <0.001* | <0.001* | <0.001* | <0.001* | ||||||||
| GnRH antagonist | 33 (21.85) | 50 (33.11) | 0.028* | 29 (28.71) | 21 (20.79) | 0.192 | 21 (29.58) | 20 (28.17) | 0.853 | 34 (32.38) | 31 (29.52) | 0.654 |
| GnRH agonist long | 71 (47.02) | 49 (32.45) | 0.010* | 41 (40.59) | 15 (14.85) | <0.001* | 21 (29.58) | 12 (16.90) | 0.074 | 24 (22.86) | 7 (6.67) | 0.001* |
| GnRH agonist ultra-long | 26 (17.22) | 7 (4.64) | <0.001* | 15 (14.85) | 4 (3.96) | 0.008* | 19 (26.76) | 2 (2.82) | <0.001* | 19 (18.10) | 4 (3.81) | 0.001* |
| GnRH agonist short | 21 (13.91) | 45 (29.80) | 0.001* | 16 (15.84) | 61 (60.40) | <0.001* | 10 (14.08) | 37 (52.11) | <0.001* | 28 (26.67) | 63 (60.00) | <0.001* |
| Duration of Gn (days) | 9.52 ± 2.15 | 9.65 ± 2.16 | 0.536 | 9.91 ± 1.98 | 9.43 ± 2.10 | 0.037* | 9.85 ± 2.09 | 9.55 ± 2.71 | 0.458 | 10.45 ± 3.30 | 9.24 ± 2.20 | 0.001* |
| Total Gn dose (IU) | 2304.64 ± 1116.89 | 2006.62 ± 893.69 | 0.001* | 2667.95 ± 940.62 | 2153.84 ± 919.26 | <0.001* | 2893.49 ± 1196.39 | 2397.75 ± 1351.87 | 0.017* | 3268.93 ± 1831.57 | 2478.21 ± 1163.91 | <0.001* |
| E2 levels on hCG day (pg/mL) | 2693.01 ± 1566.16 | 2229.32 ± 1032.86 | <0.001* | 2365.51 ± 1184.93 | 2293.50 ± 1050.46 | 0.586 | 1822.62 ± 1181.90 | 1742.50 ± 792.48 | 0.466 | 1604.78 ± 956.03 | 1484.89 ± 752.35 | 0.180 |
| Endometrial thickness on hCG day (mm) | 10.52 ± 2.01 | 10.72 ± 2.07 | 0.129 | 10.43 ± 2.21 | 9.99 ± 1.96 | 0.001* | 10.51 ± 1.91 | 10.54 ± 1.84 | 0.860 | 10.02 ± 2.41 | 9.64 ± 2.40 | 0.013* |
All values presented as mean ± SD or n (%).
GH, growth hormone; COH, controlled ovarian hyperstimulation; GnRH, gonadotropin-releasing hormone; Gn, gonadotropin; E2, estradiol; hCG, human chorionic gonadotropin.
*indicates statistical significances of p < 0.05.