Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 1;12:761922. doi: 10.3389/fphar.2021.761922

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Lu, Yu, Liang, Cheng, Wang, He, Lv, Wan, Mo, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Knockdown of integrin αVβ3 reversed the inhibition of MAPK and NF-κB signaling pathways by PA. (A) Western blotting results and (B–E) quantitative analysis of MAPK pathway related proteins (P-P38, P38, P-JNK, JNK, P-ERK, and ERK) and NF-κB pathway related proteins (P-P65, P65) from the Itg αVβ3-deficiency mice chondrocytes along with or without the administration of 5 ng/ml of IL-1β and 10 μM of PA. The non-phosphorylated protein (P38, JNK, ERK, and P65) was used as an internal control. Data are presented as means ± SD (n = 3) The exact p value was marked in the corresponding figure and p < 0.05 was considered statistically significant.