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. 2021 Dec 1;12:761922. doi: 10.3389/fphar.2021.761922

FIGURE 7.

FIGURE 7

Knockdown of integrin αVβ3 reversed the inhibition of MAPK and NF-κB signaling pathways by PA. (A) Western blotting results and (B–E) quantitative analysis of MAPK pathway related proteins (P-P38, P38, P-JNK, JNK, P-ERK, and ERK) and NF-κB pathway related proteins (P-P65, P65) from the Itg αVβ3-deficiency mice chondrocytes along with or without the administration of 5 ng/ml of IL-1β and 10 μM of PA. The non-phosphorylated protein (P38, JNK, ERK, and P65) was used as an internal control. Data are presented as means ± SD (n = 3) The exact p value was marked in the corresponding figure and p < 0.05 was considered statistically significant.