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. 2021 Dec 2;12:778978. doi: 10.3389/fimmu.2021.778978

Table 3.

Kinetic results of samples binding to PD-L1 and VEGF with a 1:1 binding model.

Ligand Enhancement Analyte Kinetics Chi2 (RU2) Ka (1/Ms) Kd (1/s) KD (M)
HB0025 Buffer VEGF165 4.30E-01 1.44E+08 6.81E-04 4.72E-12
PD-L1 VEGF165 2.31E-01 1.48E+08 4.41E-04 2.98E-12
Buffer PD-L1 1.18E-01 2.90E+05 5.10E-04 1.76E-09
VEGF165 PD-L1 6.02E-02 2.00E+05 3.95E-04 1.98E-09
HB002.1T \ VEGF165 2.01E-01 4.54E+07 5.03E-05 1.11E-12
HB0023 \ PD-L1 9.77E-02 2.34E+05 5.25E-04 2.24E-09
Bevacizumab \ VEGF165 1.91E-02 1.41E+06 6.17E-04 4.39E-10
Atezolizumab \ PD-L1 9.22E-02 1.04E+06 5.01E-04 4.82E-10