Table 5.
Direct and indirect effects of BMI on markers of glucose metabolism with SUA as a mediator.
| Outcomes | Direct effect (SUA unadjusted) | Indirect effect (SUA adjusted) | ||||
|---|---|---|---|---|---|---|
| Estimate1 (BMI to glucose metabolism) | P(c') | Estimate2 (BMI to SUA) | P(a) | Estimate3 (SUA to glucose metabolism) | P(b) | |
| FBG | -0.004 | 0.310 | 0.460 | <0.001 | 0.002 | 0.457 |
| FINS | 4.476 | <0.001 | 0.460 | <0.001 | 0.086 | 0.021 |
| HOMA-IR | 0.138 | <0.001 | 0.460 | <0.001 | 0.002 | 0.022 |
1Estimate represents the direct effect of BMI on markers of glucose metabolism.
2Estimate represents the indirect effect of BMI on SUA.
3Estimate represents the indirect effect of SUA on markers of glucose metabolism.
BMI, body mass index; SUA, serum uric acid; FBG, fasting blood glucose; FINS, fasting insulin; HOMA-IR, homeostasis model assessment-insulin resistance.