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. 2021 Jun 2;23(7):1335–1343. doi: 10.1111/jch.14296

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© 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Weighted Mean Change in Systolic Blood Pressure (SBP) from randomization at each of the first three monthly visits in antihypertensive treatment‐naive participants while on monotherapy. By the third visit, difference in mean change in SBP between chlorthalidone and amlodipine monotherapies was not significant. The following are the differences in weight mean change in SBP between chlorthalidone and amlodipine for visit 1, visit 2, and visit 3:6.23 mm Hg (p =< .001), 1.56 mm Hg (p = .586), and −5.07 mm Hg (p = .256)