FIGURE 5.

Probability of Monotherapy Failure by Monotherapy and SPRINT Treatment Group Assignment in antihypertensive treatment‐naive participants. In the treatment‐naive participants, the effects were similar to those observed in the whole group of participants. However, in the standard treatment groups, the difference in monotherapy failure rate between chlorthalidone (higher failure rate) compared with amlodipine was magnified. This difference persisted throughout the follow‐up. In the intensive treatment groups, there was no significant difference in monotherapy failure between chlorthalidone and amlodipine throughout the duration of follow‐up