TABLE 1.
Differences in demographics and characteristics in amlodipine and chlorthalidone
| Variable | Amlodipine (N = 281) | Chlorthalidone (N = 210) | p‐value |
|---|---|---|---|
| Mean age ± SD in years | 67.6 ± 9.5 | 64.2 ± 8.9 | <.001 |
| Male | 196 (70%) | 150 (71%) | .762 |
| White | 166 (59%) | 131 (62%) | .517 |
| Black | 105 (37%) | 70 (33%) | .408 |
| Other | 10 (4%) | 9 (4%) | .860 |
| Non‐hispanic | 261 (93%) | 204 (97%) | .06 |
| Mean body mass index kg/m2 | 28.1 | 29.6 | .002 |
| Use of alcohol | 14 (5%) | 9 (4%) | .884 |
| Family history of CVD | 161 (57%) | 117 (56%) | .44 |
| History of smoking | 150 (53%) | 129 (61%) | .178 |
| Non‐hypertensive medication | 34 (12%) | 33 (16%) | .319 |
| Mean SBP mm Hg at randomization | 138.2 | 144.1 | <.001 |
| Intensive treatment group | 105 (37%) | 126 (60%) | <.001 |
| History of antihypertensive use a | 211 (75%) | 34 (16%) | <.001 |
Abbreviations: CVD, cardiovascular disease; SBP, systolic blood pressure; SD, standard deviation.
a
Any hypertensive medication before randomization.