Table 2. Regression of FEV1/FVC on Main Associations of PRS and Pack-Years of Smoking and Their Cross-Product Term, Adjusting for Covariatesa.
| Variable | β (95% CI) | P value |
|---|---|---|
| PRS | −0.03 (−0.031 to −0.03) | <.001 |
| Pack-years | ||
| 11-20 | −0.011 (−0.012 to −0.01) | <.001 |
| 21-30 | −0.014 (−0.015 to −0.014) | <.001 |
| 31-40 | −0.026 (−0.027 to −0.025) | <.001 |
| 41-50 | −0.034 (−0.035 to −0.033) | <.001 |
| >50 | −0.04 (−0.041 to −0.038) | <.001 |
| PRS × pack-years category | ||
| PRS × 11-20 | −0.0038 (−0.0046 to −0.0031) | <.001 |
| PRS × 21-30 | −0.0068 (−0.0077 to −0.006) | <.001 |
| PRS × 31-40 | −0.013 (−0.014 to −0.012) | <.001 |
| PRS × 41-50 | −0.015 (−0.017 to −0.014) | <.001 |
| PRS × >50 | −0.017 (−0.019 to −0.016) | <.001 |
Abbreviations: FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; PRS, polygenic risk score.
a
Covariates include age, age×age, sex, height, genotyping array, and principal components of genetic ancestry. Pack-years of smoking is included as a categorical variable with 10 or more pack-years as the reference group.