TABLE 7.

Effect of lowering blood pressure by the HERB intervention in antihypertensive drug‐naïve participants under 65 years (n = 65)

	Mean changes at 16 weeks				Mean changes at 24 weeks
	Intervention	Controls	Adjusted difference [95% CI]	p‐Value a	Intervention	Controls	Adjusted difference [95% CI]	p‐Value a
SBP
ABPM 24 hours	−6.1	1.4	−7.6 [−13 to − 1.8]	.013	−2.7	0.54	−3.2 [−9.3 to 2.9]	.30
ABPM daytime	−4.0	3.3	−7.4 [−13 to − 1.4]	.019	0.85	2.1	−1.2 [−7.5 to 5.0]	.71
ABPM nighttime	−7.9	−2.7	−5.2 [−13 to 2.8]	.21	−7.0	−0.39	−6.7 [−15 to 1.1]	.098
Office	−5.8	−4.9	−0.92 [−6.5 to 4.7]	.75	−8.6	−8.6	−0.23 [−7.1 to 6.6]	.95
Home	−3.2	0.66	−3.8 [−8.8 to 1.2]	.14	−6.8	−1.8	−6.0 [−11 to − 1.5]	.012
DBP
ABPM 24 hours	−3.5	0.86	−4.4 [−7.7 to − 1.0]	.013	−1.6	0.32	−1.9 [−5.4 to 1.5]	.28
ABPM daytime	−1.9	1.7	−3.5 [−7.3 to 0.20]	.069	0.81	0.54	0.31 [−3.5 to 4.1]	.87
ABPM nighttime	−4.7	−0.38	−4.3 [−9.0 to 0.27]	.071	−4.6	−0.86	−5.5 [−10 to − 0.70]	.029
Office	−2.5	−1.5	−1.1 [−4.8 to 2.6]	.57	−3.7	−3.3	−0.36 [−5.6 to 4.8]	.89
Home	−3.3	−0.48	−2.9 [−6.5 to 0.72]	.12	−4.5	−1.9	−2.6 [−6.3 to 1.1]	.17

Abbreviations: ABPM, ambulatory blood pressure monitoring; DBP, diastolic blood pressure; SBP, systolic blood pressure.

^a Calculated by an ANCOVA adjusted by the use of antihypertensive medications and the mean outside temperature on the day of ABPM measurement.