TABLE 2.

Mean changes in blood pressure and pulse rate from baseline by randomization group

Follow‐up time and variable	Quadruple combination (n = 30)	Placebo (n = 30)	Between‐group difference (95% CI)	p value
Week 4
Systolic blood pressure, mmHg	−6.36 ± 1.68**	−3.10 ± 1.68	−3.26 (−8.00, 1.49)	.17
Diastolic blood pressure, mmHg	−4.50 ± 1.25**	−2.07 ± 1.25	−2.43 (−5.96, 1.11)	.17
Pulse rate, beats/min	−0.54 ± 1.63	0.37 ± 1.63	−0.90 (−5.53, 3.72)	.70
Week 8
Systolic blood pressure, mmHg	−7.95 ± 1.68**	−4.56 ± 1.68**	−3.39 (−8.16, 1.37)	.16
Diastolic blood pressure, mmHg	−5.90 ± 1.42**	−3.36 ± 1.42*	−2.54 (−6.56, 1.47)	.21
Pulse rate, beats/min	−0.68 ± 1.50	−0.07 ± 1.50	−0.60 (−4.86, 3.66)	.78
Week 12
Systolic blood pressure, mmHg	−9.78 ± 1.82**	−5.22 ± 1.82**	−4.56 (−9.71, 0.59)	.08
Diastolic blood pressure, mmHg	−6.43 ± 1.32**	−0.44 ± 1.32	−5.99 (−9.74, −2.24)	.002
Pulse rate, beats/min	−4.32 ± 1.49**	−2.29 ± 1.49	−2.04 (−6.26, 2.18)	.34

Values are least square mean ± standard error, unless otherwise indicated. CI = confidence interval.

Significance of the difference from baseline, ^* p < .05, ^** p < .01.