TABLE 3.

Cox regression analysis for incident CVD

		Cox regression model				Time‐dependent Cox regression model
		Model 1		Model 2		Model 3
		HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
baPWV	1st quartile	reference
	2nd quartile	2.02 (0.75 − 5.41)	.162
	3rd quartile	1.95 (0.73 − 5.25)	.184
	4th quartile	4.00 (1.46 − 10.98)	.007
	Per 1 m/s			1.15 (1.07 − 1.24)	<.001	1.14 (1.06 − 1.23)	<.001
CAVI	1st quartile	reference
	2nd quartile	0.98 (0.46 − 2.12)	.966
	3rd quartile	0.97 (0.46 − 2.05)	.936
	4th quartile	1.70 (0.80 − 3.63)	.167
	Per 1 unit			1.26 (1.07 − 1.48)	.006	1.23 (1.04 − 1.44)	.013

Adjusted factors in all Models were age, sex, body mass index, current smoking, mean blood pressure, heart rate, hemoglobin A1c, low‐density lipoprotein cholesterol, estimated glomerular filtration rate, urinary albumin (≥30 mg/day), and B‐type natriuretic peptide (≥100 pg/ml). Overall p values of each model for Schoenfeld residuals test were as follows: baPWV: Model 1, 0.450; Model 2, 0.352; Model 3, 0.169 and CAVI: Model 1, 0.346; Model 2, 0.518; Model 3, 0.240. Full results of the regression analysis are shown in Tables S3 and S4.

Abbreviations: baPWV, brachial‐ankle pulse wave velocity; CAVI, cardio‐ankle vascular index; CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio.