TABLE 2.

Association between adherence to antihypertensive medication within 1 year after diagnosis and CCV death in all study patients

	Adherence within 1 year after diagnosis
	CR ≥ 70		CR ≥ 80		CR ≥ 90
Outcome (cause of death)	HR (95% CI)	p‐value	HR (95% CI)	p‐value	HR (95% CI)	p‐value
All‐cause death	0.74 (0.65‐0.83)	<.0001	0.73 (0.65‐0.83)	<.0001	0.68 (0.59‐0.78)	<.0001
CCV death	0.70 (0.56‐0.89)	.004	0.68 (0.53‐0.87)	.002	0.53 (0.40‐0.71)	<.0001
Cerebrovascular disease	0.69 (0.50‐0.95)	.022	0.69 (0.49‐0.96)	.029	0.56 (0.38‐0.84)	.004
Heart failure	0.89 (0.37‐2.15)	.789	0.64 (0.26‐1.62)	.348	0.11 (0.01‐0.79)	.028
Hypertensive disease	0.55 (0.26‐1.15)	.111	0.47 (0.21‐1.05)	.065	0.32 (0.11‐0.92)	.035
Ischemic heart disease	0.87 (0.55‐1.39)	.566	0.88 (0.55‐1.41)	.595	0.84 (0.50‐1.39)	.487

Each of HR of CR ≥70, CR ≥80, and CR ≥90 was calculated based on the mortality of the non‐compliance group CR < 70, CR < 80, and CR < 90 as a reference. HR was adjusted for the following covariates: age, sex, type of medical insurance, comorbidity (diabetes mellitus, dyslipidemia), family history (hypertension, strokes, heart disease), whether CCV diseases occurred during observation period.

Abbreviations: CR, compliance ratio; HR, hazard ratio; CCV, cardio‐cerebrovascular.