TABLE 3.
Cox regression analysis for the association of urinary vanin‐1 with kidney function decline
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p ‐Value | HR (95% CI) | p ‐Value | |
| Age, ≥75 years | 2.82 (0.88‐2.82) | 0.08 | 2.23 (0.58‐8.57) | 0.25 |
| Sex | 1.18 (0.39‐3.53) | 0.76 | 0.999 (0.24‐4.15) | 0.998 |
| Smoking | 0.81 (0.18‐3.6) | 0.78 | 1.35 (0.24‐7.66) | 0.73 |
| Drinking | 0.86 (0.30‐2.49) | 0.78 | 1.80 (0.49‐6.62) | 0.37 |
| BMI, ≥25 kg/m2 | 1.44 (0.51‐4.12) | 0.49 | 0.92 (0.26‐3.23) | 0.90 |
| Antihypertensive medication | 0.12 (0.015‐0.97) | 0.046 | 0.03 (0.001‐0.58) | 0.02 |
| BP, ≥140/≥90 mmHg | 4.17 (1.40‐12.5) | 0.01 | 3.89 (1.22‐12.5) | 0.02 |
| eGFR, < 60 ml/min/1.73 m2 | 4.33 (1.19‐15.8) | 0.027 | 3.38 (0.68‐16.7) | 0.14 |
| UACR, ≥30 mg/g Cr | 3.45 (1.07‐11.1) | 0.038 | 2.96 (0.57‐15.4) | 0.19 |
| Urinary vanin‐1, ≥0.33 ng/mg Cr | 16.8 (2.14‐132.9) | <0.01 | 9.87 (1.11‐87.5) | 0.04 |
Abbreviations: 95% CI, 95% confidence interval; BMI, body mass index;BP, blood pressure; eGFR, estimated glomerular filtration rate; HR, hazard ratio; UACR, urinary albumin‐to‐creatinine ratio.