TABLE 3.
Outcomes (first hospitalization for incident myocardial infarction or stroke or heart failure, or death) by hypertension (HT) categories
| Traditional BP goal (<140/90 mmHg) |
Events Event rate |
Unadjusted HR (95% CI) P value |
Adjusted a HR (95% CI) P value |
|---|---|---|---|
|
No HT n = 5029 |
2328 events 26.3/1000 py |
0.64 (0.60‐0.69) P < .001 |
0.77 (0.71‐0.82) P < .001 |
|
Controlled HT n = 2306 |
1401 events 38.7/1000 py |
Ref. |
Ref. |
|
Untreated HT n = 1110 |
706 events 41.7/1000 py |
1.09 (1.00‐1.19) P = .06 |
1.06 (0.97‐1.16) P = .23 |
|
Uncontrolled HT n = 1034 |
715 events 48.8/1000 py |
1.31 (1.19‐1.43) P < .001 |
1.14 (1.05‐1.25) P = .004 |
|
Apparent resistant HT n = 133 |
108 events 65.3/1000 py |
1.84 (1.51‐2.23) P < .001 |
1.50 (1.23‐1.82) P < .001 |
|
Stricter BP goal (<130/80 mmHg) |
|||
|
No HT n = 3857 |
1715 events 24.9/1000 py |
0.62 (0.57‐0.68) P < .001 |
0.74 (0.68‐0.80) P < .001 |
|
Controlled HT n = 1521 |
914 events 38.0/1000 py |
Ref. | Ref. |
|
Untreated HT n = 2282 |
1319 events 36.0/1000 py |
0.94 (0.87‐1.02) P = .16 |
0.96 (0.88‐1.04) P = .33 |
|
Uncontrolled HT n = 1759 |
1163 events 45.0/1000 py |
1.22 (1.12‐1.33) P < .001 |
1.09 (1.00‐1.19) P = .06 |
|
Apparent resistant HT n = 193 |
147 events 58.2/1000 py |
1.65 (1.39‐1.97) P < .001 |
1.43 (1.20‐1.70) P < .001 |
Adjusted for baseline age, sex, race, and study center, BMI, heart rate, current smoking, eGFR, LDL, HDL, TG, and diabetes status.