Table 4.

Sensitivity and specificity of Montreal Cognitive Assessment (MoCA) for cognitive impairment in SLE

MoCA cut-off	Cognitive impairment definitions*
	2 domains 1.5 SD below		1 domain 2 SD below		2 domains 2 SD below		All 3 definitions pooled
	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity	Sensitivity	Specificity
<24	21.3%	100.0%	23.1%	98.2%	38.9%	96.1%	20.4%	100.0%
<25	36.2%	97.9%	38.5%	94.6%	61.1%	90.9%	34.7%	97.8%
<26	46.8%	93.8%	48.7%	89.3%	72.2%	84.4%	44.9%	93.5%
<27	72.3%	83.3%	74.4%	76.8%	88.9%	66.2%	69.4%	82.6%
<28	83.0%	58.3%	87.2%	55.4%	94.4%	45.5%	81.6%	58.7%
<29	91.5%	35.4%	92.3%	32.1%	100.0%	26.0%	89.8%	34.8%
<30	95.7%	20.8%	97.4%	19.6%	100.0%	15.6%	93.9%	19.6%

*Impairment defined by number of cognitive domains either 1.5 or 2 SD below healthy control group mean, all three definitions pooled into fourth cognitive impairment category.