Table 1.

Association of atrial fibrillation history with unadjusted and adjusted rate ratios for clinical outcomes (reference group is patients with no history of atrial fibrillation)

Outcome	Unadjusted RR (95% CI)	P value	Adjusted RR (95% CI)*†	P value
All-cause mortality	2.16 (1.57 to 2.98)	<0.001	0.98 (0.70 to 1.38)	0.93
Bleeding event requiring hospitalisation	2.61 (1.58 to 4.30)	<0.001	1.64 (0.96 to 2.82)	0.07
All-cause hospitalisation	1.76 (1.50 to 2.06)	<0.001	1.25 (1.06 to 1.46)	0.008
Primary composite	1.61 (1.26 to 2.06)	<0.001	0.92 (0.71 to 1.20)	0.53
Secondary composite	2.07 (1.57 to 2.73)	<0.001	1.15 (0.86 to 1.55)	0.35

Primary composite=all-cause mortality, myocardial infarction, stroke, unstable angina with urgent revascularisation. Secondary composite=cardiovascular mortality, myocardial infarction, stroke.

*Composite, all-cause mortality and bleeding requiring hospitalisation outcomes adjusted for variables in the TIGRIS risk index model: age ≥65 years, diabetes, second prior MI, chronic kidney disease, heart failure, peripheral artery disease, major bleed, medical management of index MI, diuretics, region and country as random effects.

†All-cause hospitalisation outcome (from 7170 patients with complete hospitalisation data) adjusted for predictors of all-cause hospitalisation: cardiovascular event requiring hospital stay 6 months before enrolment, diuretic, chronic kidney disease, age ≥65 years, second prior MI, diabetes, history of cancer, permanent pacemaker, history of COPD, systolic blood pressure, implantable cardioverter defibrillator, history of major bleed, history of angina, cardiologist visit 6 months before enrolment, region, statin or other lipid-lowering drug and history of anaemia.

COPD, chronic obstructive pulmonary disease; CV, cardiovascular; MI, myocardial infarction; RR, rate ratio; TIGRIS, long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease registry.