Table III.
Elevated sialidase and fecundability.
| Periconceptual exposure | Menstrual cycles exposed (n %) | Pregnancies (n %) | Unadjusted FR (95% CI) | Adjusted FR (95% CI)i | |
|---|---|---|---|---|---|
| Primary analysis | n = 1376 | n = 255 | |||
| Elevated sialidase at the visit prior to pregnancy test ii | 448 (32.6) | 82 (32.2) | 0.99 (0.77, 1.26) | 0.99 (0.77, 1.27) | |
| Secondary analyses | |||||
| Elevated sialidase at enrollment | 463 (33.7) | 87 (34.1) | 1.02 (0.81, 1.29) | 1.03 (0.81, 1.31) | |
| Persistent elevated sialidase: visit before and at pregnancy test | |||||
| Prior visit | Current visit | n = 1373 | n = 252 | ||
| No | No | 831 (60.5) | 151 (59.9) | Ref | Ref |
| Yes | No | 130 (9.5) | 43 (17.1) | 1.82 (1.34, 2.46) | 1.76 (1.30, 2.38) |
| No | Yes | 95 (6.9) | 20 (7.9) | 1.15 (0.75, 1.76) | 1.13 (0.74, 1.72) |
| Yes | Yes | 317 (23.1) | 38 (15.1) | 0.66 (0.47, 0.92) | 0.67 (0.48, 0.94) |
| Persistent elevated sialidase: two visits prior iii | |||||
| Two visits prior | One visit prior | n = 679 | n = 174 | ||
| No | No | 385 (56.7) | 98 (56.3) | Ref | Ref |
| Yes | No | 77 (11.3) | 25 (14.4) | 1.09 (0.78, 1.51) | 1.09 (0.78, 1.51) |
| No | Yes | 70 (10.3) | 18 (10.3) | 1.00 (0.66, 1.51) | 0.97 (0.65, 1.45) |
| Yes | Yes | 147 (21.7) | 33 (19.0) | 0.90 (0.64, 1.28) | 0.93 (0.66, 1.31) |
FR, fecundability ratio.
i
Adjusted for age, study site and frequency of condomless sex in last 4 weeks.
ii
Lagged, time-varying exposure.
iii
Unadjusted and adjusted fecundability models in the analyses assessing the association between elevated sialidase at the two visits prior to each pregnancy test were run using the Poisson family due to convergence issues with the adjusted models and reduced sample size.