Table 2.

Druglikeness of the most suited ligands to the active site of angiotensin converting enzyme type-2 receptor. The compound no. 5 (epicatechin) and compound no. 22 (kempferol) proved the best pharmacokinetics, druglikeness, and toxicity features over all other tested compounds.

No.	Compound	GI absorption	Druglikeness					Toxicity
			Lipinski rules violations	Ghose rules	Veber rules	Egan rules	Muegge rules	Hepatoxicity	Carcinogenicity	Immunotoxicity	Mutagenicity	Cytotoxicity
1	Delphinidin	High	1 violation	Yes	Yes	1 violation	1 violation	Inactive	Active	Inactive	Inactive	Inactive
2	Cyanidin	High	Yes	Yes	Yes	Yes	Yes	Inactive	Active	Inactive	Inactive	Inactive
3	delphinidin 3-(6″-malonylglucoside)-5-malonylglucoside)	Low	3 violations	4 violations	2 violations	1 violation	5 violations	Inactive	Inactive	Inactive	Inactive	Inactive
4	Epigallocatechin	High	1 violation	Yes	Yes	Yes	1 violation	Inactive	Inactive	Inactive	Inactive	Inactive
5	Epicatechin	High	Yes	Yes	Yes	Yes	Yes	Inactive	Inactive	Inactive	Inactive	Inactive
6	Petunidin	High	Yes	Yes	Yes	Yes	Yes	Inactive	Active	Active	Inactive	Inactive
7	Alyssonoside	Low	3 violations	4 violations	2 violations	1 violation	4 violations	Inactive	Inactive	Active	Inactive	Inactive
8	Foeniculoside I	Low	3 violations	3 violations	1 violation	1 violation	6 violations	Inactive	Inactive	Active	Inactive	Inactive
9	Medicoside I	Low	3 violations	4 violations	2 violations	1 violation	5 violations	Inactive	Inactive	Active	Inactive	Inactive
10	Acteoside	Low	3 violations	4 violations	2 violations	1 violation	4 violations	Inactive	Inactive	Active	Inactive	Inactive
11	Protodegalactotigonin	Low	3 violations	4 violations	2 violations	1 violation	7 violations	Active	Inactive	Active	Inactive	Inactive
12	Aloins	Low	Yes	1 violation	1 violation	1 violation	Yes	Active	Inactive	Active	Inactive	Inactive
13	Cynarotrioside	Low	3 violations	4 violations	1 violation	1 violation	4 violations	Inactive	Inactive	Active	Inactive	Inactive
14	Serotonin	High	Yes	Yes	Yes	Yes	1 violation	Inactive	Inactive	Inactive	Inactive	Inactive
15	Luteolin 7-rutinoside-4′-glucoside	Low	3 violations	4 violations	1 violation	1 violation	4 violations	Active	Inactive	Active	Inactive	Inactive
16	Medicoside J	Low	3 violations	4 violations	2 violations	1 violation	5 violations	Inactive	Inactive	Active	Inactive	Inactive
17	Myricetin 3-robinobioside-7-rhamnoside	Low	3 violations	4 violations	1 violation	1 violation	4 violations	Inactive	Inactive	Active	Inactive	Inactive
18	Isoeruboside B	Low	3 violations	4 violations	2 violations	1 violation	5 violations	Inactive	Inactive	Active	Inactive	Inactive
19	Terminalic Acid	Low	3 violations	3 violations	1 violation	1 violation	4 violations	Inactive	Inactive	Active	Active	Inactive
20	3′-Methoxy apiin	Low	3 violations	4 violations	1 violation	1 violation	3 violations	Inactive	Inactive	Active	Inactive	Inactive
21	Ceposide D	Low	3 violations	4 violations	2 violations	1 violation	5 violations	Active	Inactive	Active	Inactive	Inactive
22	Chrysazol	Low	Yes	Yes	Yes	Yes	Yes	Inactive	Inactive	Inactive	Active	Inactive
23	Kempferol (control)	High	Yes	Yes	Yes	Yes	Yes	Inactive	Inactive	Inactive	Inactive	Inactive