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RDO24_mIgG2a and RDO24_mFab2, but not RDO24_mFab, trigger MET biological activity. HGF (0.5 nM) and mAbs (50 nM) were tested for scatter effect in epithelial MDCK cells (A), X-Celligence cell migration assay in HPAF-II cells (B), and wound-healing assay in H9c2 cardiomyoblasts cells (C). Data analysis in (B, C) were obtained from three independent experiments. ***Pvalue < 0.001 significant vs Control; *Pvalue < 0.05 significant vs Control.
