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Effect of treatment with CRF1 receptor antagonists on CAH biomarkers. (A) Percentage fall in 17OHP and androstenedione (A4) after 14 days of Crinecerfont oral dosing: 50 mg at bedtime (n = 8), 100 mg at bedtime (n = 7), 100 mg once daily with an evening meal (n = 8), and 100 mg twice daily with meals (n = 8). (B) Percentage fall in 17OHP and A4 during Tildacerfont treatment in patients with poor control of CAH at baseline.
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