Figure 5.

Chronocort phase 3 and extension study. (A) 24-h profile of 17OHP levels at 24 weeks comparing titrated standard treatment and Chronocort showing that Chronocort improves morning control of 17OHP. (B and C) 24-h profiles of 17OHP and A4 at baseline and after 24 weeks showing that Chronocort normalizes 17OHP levels and this is associated with low levels of A4. (D) 9:00 h 17OHP levels during Chronocort treatment from the phase 3 through the 18 months extension study compared to median hydrocortisone dose showing that during the extension study the hydrocortisone dose came down to a median dose of 20 mg and control of 17OHP was maintained (note right y axis represents current hydrocortisone dose range used in patients with CAH). Hormone levels are shown as geometric mean ± 95% CI (adapted from Merke et al. (47)).