Table 3.
Within-group changes in metabolic syndrome and metabolic parameters from baseline to 12 months. Differences were tested with multilevel logistic regression analyses for categorical variables and with multilevel linear regression analyses for continuous variables, combined with a bootstrap procedure in case of a non-normal distribution.
| Group | At baseline | At 3 months | At 6 months | At 9 months | At 12 months | Change | P value within |
|---|---|---|---|---|---|---|---|
| Metabolic syndrome (%) | |||||||
| SMS+ | 41.9 | 32.4 | 28.9 | 26.8 | 25.3 | −16.5 | 0.190 |
| SMS− | 49.8 | 37.6 | 32.9 | 30.2 | 28.2 | −21.6 | 0.037 |
| CAU | 37.9 | 41.6 | 43.1 | 44.1 | 44.8 | 7.0 | 0.509 |
| Metabolic parameters | |||||||
| cMetS z-score | |||||||
| SMS+ | 0.44 | 0.20 | 0.11 | 0.06 | 0.02 | −0.42 | 0.002 |
| SMS− | 0.41 | 0.19 | 0.16 | 0.17 | 0.20 | −0.21 | 0.027 |
| CAU | 0.39 | 0.22 | 0.23 | 0.28 | 0.36 | −0.03 | 0.733 |
| HOMA-IR | |||||||
| SMS+ | 3.33 | 3.12 | 3.04 | 2.99 | 2.95 | −0.38 | 0.329 |
| SMS− | 3.79 | 3.70 | 3.67 | 3.65 | 3.63 | −0.15 | 0.658 |
| CAU | 3.87 | 3.81 | 3.79 | 3.78 | 3.76 | −0.11 | 0.842 |
| SBP (mmHg) | |||||||
| SMS+ | 120 | 117 | 116 | 115 | 115 | −5 | 0.053 |
| SMS− | 121 | 119 | 117 | 117 | 116 | −5 | 0.010 |
| CAU | 119 | 120 | 120 | 120 | 121 | 1 | 0.450 |
| DBP (mmHg) | |||||||
| SMS+ | 78 | 76 | 75 | 75 | 74 | −4 | 0.034 |
| SMS− | 79 | 77 | 77 | 76 | 76 | −3 | 0.040 |
| CAU | 78 | 78 | 78 | 78 | 78 | 0 | 0.821 |
| Waist (cm) | |||||||
| SMS+ | 102.9 | 98.4 | 96.5 | 95.4 | 94.5 | −8.4 | 0.013 |
| SMS− | 100.1 | 98.1 | 97.2 | 96.7 | 96.3 | −3.7 | 0.097 |
| CAU | 100.3 | 97.6 | 96.5 | 95.8 | 95.2 | −5.1 | 0.016 |
| Glucose (mmol/L) | |||||||
| SMS+ | 5.1 | 5.0 | 5.0 | 5.0 | 5.0 | −0.2 | 0.150 |
| SMS− | 5.2 | 5.1 | 5.1 | 5.1 | 5.1 | −0.1 | 0.371 |
| CAU | 5.0 | 5.1 | 5.1 | 5.1 | 5.2 | 0.1 | 0.375 |
| Insulin (pmol/L) | |||||||
| SMS+ | 100 | 94 | 92 | 90 | 89 | −11 | 0.376 |
| SMS− | 111 | 110 | 110 | 110 | 110 | −2 | 0.842 |
| CAU | 118 | 114 | 113 | 112 | 111 | −8 | 0.700 |
| Cholesterol (mmol/L) | |||||||
| SMS+ | 4.7 | 4.5 | 4.4 | 4.4 | 4.3 | −0.4 | 0.009 |
| SMS− | 4.8 | 4.7 | 4.7 | 4.6 | 4.6 | −0.2 | 0.092 |
| CAU | 4.7 | 4.7 | 4.7 | 4.7 | 4.7 | 0.0 | 0.836 |
| HDL (mmol/L) | |||||||
| SMS+ | 0.94 | 0.92 | 0.91 | 0.90 | 0.90 | −0.04 | 0.200 |
| SMS− | 0.95 | 0.96 | 0.96 | 0.96 | 0.97 | 0.02 | 0.643 |
| CAU | 0.87 | 0.90 | 0.92 | 0.92 | 0.93 | 0.06 | 0.022 |
| LDL (mmol/L) | |||||||
| SMS+ | 3.21 | 3.05 | 2.99 | 2.94 | 2.91 | −0.29 | 0.027 |
| SMS− | 3.24 | 3.15 | 3.11 | 3.09 | 3.07 | −0.17 | 0.115 |
| CAU | 3.25 | 3.19 | 3.16 | 3.15 | 3.14 | −0.11 | 0.281 |
| TG (mmol/L) | |||||||
| SMS+ | 1.33 | 1.27 | 1.25 | 1.23 | 1.22 | −0.11 | 0.441 |
| SMS− | 1.39 | 1.31 | 1.28 | 1.26 | 1.24 | −0.15 | 0.065 |
| CAU | 1.39 | 1.42 | 1.43 | 1.44 | 1.45 | 0.06 | 0.593 |
CAU, care as usual; cMetS z-score, continuous metabolic syndrome Z score; DBP, diastolic blood pressure; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment for insulin resistance; LDL, low-density lipoprotein; SBP, systolic blood pressure; SMS−, lifestyle intervention without SMS support; SMS+, lifestyle intervention with SMS support; TG, triglyceride.
Statistically significant values (P<0.05) are presented in bold.
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