Table 2.

Estrogen metabolism in premenopausal patients.

Estrogens and estrogen metabolites	Invasive breast cancer 50th (25th, 75th)	Breast fibroadenoma 50th (25th, 75th)	P
Parent estrogens	6.35 (4.29, 8.78)	4.45 (3.09, 8.59)	0.420
Estrone	4.09 (3.03, 5.29)	4.32 (2.79, 8.01)	0.466
Estradiol	2.04 (1.44, 3.84)	2.81 (1.54, 4.54)	0.305
2-Hydroxylation pathway	1.90 (1.21, 3.57)	3.11 (1.86, 6.19)	0.065
2-OHE1	1.03 (0.51, 2.49)	1.49 (0.56, 2.62)	0.484
2-OHE2	0.11 (0, 0.47)	0.73 (0, 1.44)	0.022
2-MeOE1	0.51 (0.36, 0.67)	0.58 (0.34, 0.92)	0.266
4-Hydroxylation pathway	0.31 (0.04, 0.82)	0.62 (0.11, 1.58)	0.152
4-OHE1	0.25 (0, 0.69)	0.34 (0, 1.43)	0.458
4-OHE2	0 (0, 0.06)	0 (0, 0.18)	0.113
4-MeOE1	0 (0, 0.01)	0 (0, 0.01)	0.708
16-Hydroxylation pathway	3.43 (1.93, 5.64)	4.11 (2.15, 10.42)	0.298
16α-OHE1	0.54 (0.34, 0.98)	0.68 (0.31, 2.22)	0.226
Estriol	2.71 (1.55, 4.71)	3.11 (1.63, 8.02)	0.396
Total estrogens/estrogen metabolites	9.25 (7.87, 19.80)	10.17 (8.90, 23.45)	0.108

Bold indicates statistical significance, P < 0.05.