Table 3.

Estrogen metabolism in postmenopausal patients.

Estrogens and estrogen metabolites	Invasive breast cancer 50th (25th, 75th)	Breast fibroadenoma 50th (25th, 75th)	P
Parent estrogens	3.14 (1.39, 4.86)	4.45 (2.93, 9.20)	0.464
Estrone	1.81 (0.76, 3.87)	3.11 (1.71, 5.25)	0.488
Estradiol	0.63 (0.31, 1.15)	1.54 (0.92, 3.45)	0.300
2-Hydroxylation pathway	1.09 (0.48, 2.21)	2.30 (1.53, 4.59)	0.028
2-OHE1	0.24 (0.02, 0.70)	0.83 (0.46, 1.87)	0.029
2-OHE2	0.32 (0.00, 0.92)	0.89 (0.34, 1.31)	0.006
2-MeOE1	0.25 (0.14, 0.51)	0.41 (0.26, 0.71)	0.071
4-Hydroxylation pathway	0.53 (0.09, 1.32)	0.87 (0.51, 1.50)	0.027
4-OHE1	0.45 (0.00, 1.32)	0.44 (0.24, 0.81)	0.539
4-OHE2	0.00 (0.00, 0.08)	0.13 (0.00, 0.24)	<0.001
4-MeOE1	0.00 (0.00, 0.11)	0.07 (0.00, 0.25)	<0.001
16-Hydroxylation pathway	1.08 (0.36, 1.84)	2.45 (0.78, 6.41)	0.297
16α-OHE1	0.16 (0.06, 0.33)	0.58 (0.23, 1.89)	<0.001
Estriol	0.85 (0.26, 1.45)	1.89 (0.45, 5.18)	0.979
Total estrogens/estrogen metabolites	6.68 (4.15, 10.37)	12.15 (6.86, 24.53)	0.193

Bold indicates statistical significance, P < 0.05.