Table 2.

Clinical Details of the patients (n  = 20) who had AI among those with euvolaemic hyponatremia.

		Age	Sex	Admitting symptoms	Primary diagnosis	Basal cortisola	Post-APST cortisola	Clinical suspicionb	Final cause of AIc
1	PS	26	F	Fever/headache	Tuberculous meningitis	7.4	17.6	Not suspected	TB-related isolated SAI. Hyponatremia responded to steroids
2	JK	57	F	Nausea/vomiting	Acute gastritis	3.6	12.5	Not suspected	Hypopituitarism likely Sheehan’s syndrome. Hyponatremia responded to steroids
3	GS	67	M	Cough/breathlessness	AE of COPD	3.77	3.57	Not suspected	SAI to inhaled steroids. Hyponatremia responded to steroids
4	KK	55	F	Fever/confusion	CAP	2.1	Not done	Suspected	Primary AI. Hyponatremia responded to steroids
5	PK	43	F	Fever/cough	CAP with AKI	6.25	10.45	Suspected	SAI due to undocumented oral steroid use. Hyponatremia responded to steroids
6	PS	63	F	Confusion/vomiting	Organophosphorus poisoning	3.32	11.3	Not suspected	Hypopituitarism likely Sheehan’s syndrome. Hyponatremia responded to steroids
7	RK	62	M	Fever/cough	AE of COPD	5	17	Not suspected	SAI to inhaled steroids. Hyponatremia responded to steroids
8	SK	61	F	Syncope/right-sided weakness	Left internal capsule bleed	12.4	15.4	Not suspected	Hypopituitarism likely Sheehan’s syndrome. Hyponatremia responded to steroids
9	RS	55	M	Epistaxis	Hypertensive nasal bleed	3.4	13.8	Not suspected	SAI due to undocumented steroids. Hyponatremia responded to steroids
10	SK	48	F	Fever/cough	CAP	13.3	16.4	Not suspected	SAI due to indigenous medication-containing steroids. Hyponatremia responded to steroids
11	JK	54	M	Fever/headache	Scrub typhus/new diagnosis of Primary Hypothyroidism	8.8	15.3	Not suspected	Relative SAI likely because of untreated hypothyroidism. Hyponatremia responded to steroids
12	ML	50	M	Cough/breathlessness	AE of COPD	2.9	9.9	Not suspected	SAI to inhaled steroids. Hyponatremia responded to steroids
13	IK	65	M	Cough/breathlessness	AE of COPD	6	10.1	Suspected	SAI to inhaled steroids. Hyponatremia responded to steroids
14	SE	65	F	Fever/headache	Urosepsis/rheumatoid arthritis	8.22	11.8	Not suspected	SAI due to indigenous medication-containing steroids. Hyponatremia responded to steroids
15	JS	50	M	Altered sensorium	ALD/vitiligo	2.4	12.8	Not suspected	Hypopituitarism possible Lymphocytic hypophysitis. Hyponatremia responded to steroids
26	SS	60	M	Seizure	Alcohol withdrawal seizures/ALD	5.5	12.9	Not suspected	Etiology unclear/low albumin and malnutrition. Hyponatremia did not respond to steroids
17	VK	59	M	Vomiting	T2DM/acute gastritis	5	12.8	Suspected	Primary AI. Hyponatremia responded to steroids
18	JS	63	M	Vertigo/headache	Right posterior circulation stroke	0.6	13.4	Not suspected	SAI due to indigenous medication-containing steroids. Hyponatremia responded to steroids
19	CS	26	F	Fever	Systemic lupus erythematosus	2.7	13.7	Not suspected	Hypopituitarism etiology unclear. Hyponatremia responded to steroids
20	HS	75	M	Fall	Acute inflammatory demyelinating polyneuropathy	8.33	17.7	Not suspected	AI etiology unclear. However, result was borderline. Hyponatremia however responded to steroids

^aμg/dL; ^b If adrenal disease was suspected by treating physician prior to enrolment into study; ^cEtiology of AI as per endocrinology assessment.

AE, acute exacerbation; AI, adrenal insufficiency; AKI, acute kidney injury; ALD, alcoholic liver disease; CAP, community-acquired pneumonia; SAI, secondary adrenal insufficiency; T2DM, type 2 diabetes mellitus.