Table 1.

Baseline characteristics of lung cancer cases and matched controls nested in CLUE I/II

	Controls	Cases
		All lung cancers	Non-small cell lung cancer	Small cell lung cancer
N	208	208	150	29
Median age (range, years)	56 [28, 81]	59 [30, 83]	58 [36, 83]	53 [30, 71]
Median time before diagnosis (range, years)		14 [0, 29]	14 [0, 28]	12 [2, 29]
Sex
Male	95 (45.7%)	95 (45.7%)	61 (40.7%)	16 (55.2%)
Female	113 (54.3%)	113 (54.3%)	89 (59.3%)	13 (44.8%)
Race
White	208 (100%)	205 (98.6%)	149 (99.3%)	28 (96.6%)
Black	0 (0%)	3 (1.4%)	1 (0.7%)	1 (3.4%)
Cigarette smoking status
Never smoker	22 (10.6%)	22 (10.6%)	15 (10.0%)	1 (3.4%)
Ever smoker	80 (38.5%)	80 (38.5%)	56 (37.3%)	10 (34.5%)
Current smoker	106 (51.0%)	106 (51.0%)	79 (52.7%)	18 (62.1%)
Median cigarette smoking Intensity (range, cig/day)	20 [0, 80]	20 [0, 80]	20 [0, 70]	20 [0, 80]
Cigar or pipe smoking
Never	176 (84.6%)	178 (85.6%)	132 (88.0%)	25 (86.2%)
Ever	28 (13.5%)	26 (12.5%)	15 (10.0%)	4 (13.8%)
Current	4 (1.9%)	4 (1.9%)	3 (2.0%)	0 (0%)
Median BMI, kg/m2 (range)	25.8 [18.0, 40.9]	25.6 [15.5, 42.6]	25.4 [15.5, 42.6]	25.6 [18.3, 34.7]
mdNLR mean (SD)	1.74 (0.976)	1.86 (1.32)	1.85 (1.19)	1.65 (1.07)
mdNLR median (range)	1.58 [0.13, 6.42]	1.59 [0.28, 11.90]	1.56 [0.28, 9.45]	1.44 [0.39, 4.81]
CRP score 1 mean (SD)	0.02 (1.01)	− 0.02 (0.99)	− 0.04 (0.97)	0.47 (1.08)
CRP score 1 median (range)	0.06 [− 2.42, 2.99]	− 0.03 [− 3.26, 2.94]	− 0.03 [− 3.26, 2.94]	0.41 [− 1.93, 2.16]
CRP score 2 mean (SD)	0.04 (1.03)	− 0.04 (0.98)	− 0.06 (0.95)	0.36 (1.17)
CRP score 2 median (range)	0.01 [− 3.35, 3.93]	− 0.10 [− 2.68, 3.10]	− 0.11 [− 2.68, 3.10]	0.24 [− 2.34, 3.10]
CRP score 3 mean (SD)	− 0.06 (0.98)	0.06 (1.02)	0.09 (1.03)	0.32 (0.97)
CRP score 3 median (range)	− 0.09 [− 2.43, 2.51]	0.08 [− 2.34, 2.95]	0.10 [− 2.34, 2.95]	0.38 [− 2.19, 1.97]