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. 2021 Dec 16;19:267. doi: 10.1186/s12915-021-01204-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CiRNAseq provides genus-level microbiome profiling as 16S rRNA-seq but offers improved taxonomic resolution. A 16S rRNA-seq (SN-A) and CiRNAseq (SN-B) possess similar sequencing capacity when differentiating 31 of the 38 genera analyzed. The methods gave the same results with respect to quantifying the genera Lactobacillus, Gardnerella, Atopobium, and Megasphaera. The microbial composition of samples A and B is similar when analyzed using the two sequencing techniques. Microbial species and isolates URC were summed to show the results at the genus level. B CiRNAseq allows detecting bacteria at high-resolution. The technique suggested 24 different bacterial species, including two species of Anaerococcus, seven Lactobacillus species, five species of Prevotella, and two species of Sneathia. For A, values represent the relative abundances of each microbe in the sample. Bacterial species isolates within our CVMP were considered for display of B