Table 1. – Demographic data, clinical and laboratory data of COVID-19 pediatric patients with and without multisystem inflammatory syndrome in children (MIS-C), according to the World Health Organization criteria (WHO).

Demographic, clinical and laboratory data	MIS-C ( n = 20)	Non-MIS-C ( n = 28)	p
Age (years)	8.4 (0.1-16.4)	6.7 (0 – 18.6)	0.33
Sex (male)	10 (50%)	17 (60.7%)	0.56
Preexisting diseases	15 (75%)	20 (71.4%)	1
Respiratory symptoms	10 (50%)	14 (50%)	1
Gastrointestinal symptoms	6 (30%)	7 (25%)	0.75
Rash/ Non-purulent bilateral conjunctivitis/mucocutaneous inflammation signs	1 (5%)	0 (0%)	0.41
Seizures	5 (25%)	0 (0%)	0.009
Shock	12 (60%)	0 (0%)	<0.0001
Evidence of coagulopathy (↑PT, ↑PTT, ↑D-dimer)	20 (100%)	18 (64.3%)	0.0028
Anemia*	14 (70%)	21 (75%)	0.75
Thrombocytopenia**	4 (20%)	7 (25%)	0.74
Lymphocytopenia***	8 (40%)	14 (50%)	0.56
Echocardiographic abnormalities	19 (95%)	4 (14.3%)	<0.0001
D-dimers (ng/ml)****	9652.5 (921 - 115668)	1722 (190 - 95040)	0.0003
C-reactive protein (mg/L)****	119.6 (0.38 - 447.7)	14.6 (0.30 – 324)	0.0046
Ferritin (ng/ml)****	1159 (58-35967)	655 (25-2567)	0.07
Troponin (ng/L)****	25 (9-385)	16 (3-1050)	0.028
Creatine kinase (CK-MB) (ng/ml)****	1.78 (0.3-30)	1.65 (0.18-28.9)	1
Death	7 (35%)	0 (0%)	0.001
Confirmation of Sars-CoV-2 infection (RT-PCR/serology)	11 (55%)	28 (100%)	0.0001

Values are expressed as n (%) or as median (range). Fisher exact test was used to compare categorical data. Mann-Whitney U test was used to compare non-normally distributed continuous variables. *Hematocrit at or below 2.5^thpercentile for age, race, and sex at admission. **Platelet count < 100000/microL at admission; ***Lymphocyte count < 4,500/mm³in children under 8 months and < 1500/mm³in older ones at admission; ****Values correspond to the highest serum level obtained from each patient. PT: prothrombin time; PTT: partial thromboplastin time