Figure 7.

Comparison of association effect sizes in Europeans versus South Asians for the top five variants in the South Asian and European regression models for the MHC region

In (A) and (B), the log(OR) of each variant in the South Asian model as estimated in the European dataset is plotted against their estimates in the South Asian dataset. Conversely, in (C) and (D), the log(OR) of each of the top five variants in the European model as estimated in the South Asian dataset is plotted against their estimates in the European dataset. (A) and (C) plot effect sizes for the final regression model containing all variants; (B) and (D) plot unconditional effect sizes for each variant with no other variants in the regression model. Multiallelic variants with m alleles are represented by the set of m − 1 decomposed biallelic variants used for the joint Wald test. The vertical and horizontal bars show the 95% confidence intervals for these estimates in each dataset. Green and red lines depict a 1:1 correspondence and a linear fit, respectively. The Pearson correlation coefficient and its significance are shown in the upper left corner of each plot.