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. 2021 Dec 6;49(22):12943–12954. doi: 10.1093/nar/gkab1172

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Library of ribosomal frameshifting reporter variants. (A) A cartoon depicts the structure of a reporter that generates a fluorescent protein (mKate) as a result of −1PRF in the SINV structural polyprotein (top). A library of reporter variants was generated by randomizing every 0-frame codon within a region ranging from residues 696−817 (bottom). (B) A histogram depicts the range of single-cell mKate: GFP intensity ratios among recombinant stable cells expressing the WT reporter (black) or the library of reporter variants (red).