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. 2021 Dec 6;49(22):13092–13107. doi: 10.1093/nar/gkab1180

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — SPACE reveals RBPs as a major component of chromatome. (A) The frequency of RBPs in the entire proteins enriched by SPACE were shown as counts and relative iBAQ. (B) Comparing proteins enriched by SPACE with RICK (33) and CARIC (34) datasets. The latter two datasets enrich RBPs that interact with newly transcribed RNA. (C) Enriched proteins by SPACE were ranked by their relative iBAQ. The rates of accumulation in the dataset were compared among 1: known DNA/Chromatin-binders, including known caRBPs (continuous green line), 2: proteins that overlap with RICK and CARIC (dash purple line), 3: other RBPs (dot-dash purple line) and 4: other proteins (dot black line). (D) The proportion of RBPs in DNA/chromatin-binding proteins (left bars), protein present in nucleus (middle bars), and unexpected proteins (right bars) were shown as count and relative iBAQ.