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. 2021 Dec 6;49(22):13045–13061. doi: 10.1093/nar/gkab1148

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — HDNMT2 methylates only tRNA^Gly(GCC) and tRNA^Asp(GUC) among all the thirteen human cytoplasmic tRNA transcripts containing C38. (A) Schematic diagrams of all the thirteen human cytoplasmic tRNAs containing C38: two tRNA^Gly isoacceptors, tRNA^His(GUG), three tRNA^Val isoacceptors, tRNA^Asp(GUC), two tRNA^Ala isoacceptors, two tRNA^Glu isoacceptors, and two tRNA^Leu isoacceptors. (B–E) The capacity of the thirteen human cytoplasmic C38-containing tRNAs to be methylated by hDNMT2.