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. 2021 Dec 6;49(22):13045–13061. doi: 10.1093/nar/gkab1148

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — G34 or I34 function as the determinants for hDNMT2 recognition. (A) The formulas of guanosine (G), inosine (I) and adenosine (A). (B) The secondary structures of tRNA^Gly(GCC), -(CCC) and tRNA^Val(AAC). The capacity of tRNA^Gly(GCC) with various mutations at position 34 (C), 46 (D) and 57 (E) to be methylated by hDNMT2. (F) The capacity of tRNA^Val(AAC) and -A34G to be methylated by hDNMT2.