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Nth linker 1 sequences. The linker sequences for hNTHL1, EcoNth, and hNTHL1Δ63 chimera are listed. The human linker (linker 1) was substituted with the corresponding EcoNth linker. The last four residues (KVRR) are an extension of helix B and were therefore left in the hNTHL1Δ63 chimera to not disrupt local secondary structure elements.
| Construct | Linker sequence |
|---|---|
| hNTHL1Δ63 | VDHLGTEHCYDSSAPKVRR |
| hNTHL1Δ63 chimera | TTELNFSSPKVRR |
| EcoNth | TTELNFSSP |
