Table 2. Estimated crude and adjusted odd ratios for telomeres longer than median (long RTL) in neonate, as predicted by maternal regular opioid use.

	Crude model		Adjusted Model 1		Adjusted Model 2		Adjusted Model 3
Long RTL	OR(95% CI)	p-value	OR(95% CI)	p-value	OR(95% CI)	p-value	OR(95% CI)	p-value
Maternal regular opioid use (OM)	1.86 (0.64–5.4)	0.25	1.77 (0.61–5.16)	0.29*	1.93 (0.57–6.52)	0.28**	1.48 (0.43–5.10)	0.532***
Maternal regular smoking	2.05 (0.55–7.67)	0.28	1.91 (0.49–7.39)	0.346 *	2.14 (0.55–8.24)	0.269**	1.66 0.35–7.80)	0.517****
Sensitivity analysis by sex
Maternal regular opioid use (OM), Sons	5.5 (1.14–26.41)	0.03	4.95 (10.1–24.31)	0.04 #	7.3 (1.05–51.81)	0.04 ##	5 (0.70–35.49)	0.108###
Maternal regular opioid use (OM), Daughters	0.57 (0.11–2.75)	0.48	0.49 (0.09–2.69)	0.42#	0.53 (0.09–3.11)	0.49##	0.5 (0.08–2.80)	0.431###
Maternal smoking, Sons	3.6 (0.59–21.93)	0.165	3.17 (0.48–20.77)	0.228#	3.30 (0.50–21.73)	0.214##	1.2 (0.12–11.86)	0.876####
Maternal smoking, Daughters	1.03 (0.14–7.52)	0.97	1.33 (0.16–10.62)	0.782#	1.02 (0.14–7.48)	0.981##	1.5 0.17–13.22)	0.715####

OR: odd ratio, CI: confidence interval.

Long RTL: relative telomere length higher>median.

*Adjusted for sex and Mother’s age.

**Adjusted for sex and Mother’s education.

***Adjusted for sex and Mother’s smoking.

**** Adjusted for sex and Mother’s regular opioid use (OM).

^#Adjusted for Mother’s age.

^##Adjusted for Mother’s education.

^### Adjusted for Mother’s smoking.

^####Adjusted for Mother’s regular opioid use (OM).