Table 3. Mediation (suppressor) effect of neonate weight on the association between OM and long telomere.

	Model 1		Model 2*			Model 3**
Long RTL	OR(95% CI)	p-value	OR(95% CI)	p-value	Mediation Proportion	OR(95% CI)	p-value	Mediation Proportion
Mother opioid use, Sons	5.5 (1.14–26.41)	0.033	13.5 (1.38–131.42)	0.025	-177%	5.5 (1.05–29.71)	0.043	-2%

% Mediation proportion: the degree to which neonate weight or BMI categorical parameter might mediate (suppresses) the effect of OM on neonate RTL.

*Intermediate parameter (heavy birth weight) added to the model.

**Intermediate parameter (high birth BMI) added to the model.

Long RTL: RTL longer than median.

Heavy birth weight: neonate weight higher than median.

OM: opioid using mother, RTL: relative telomere length, CI: confidence interval.