Table 3. Baseline and final objective dry eye parameters for a longitudinal, clinic-based sample of patients with Sjögren’s and non-Sjögren’s dry eye disease.
| Ocular Surface and Tear Film Parameter | All Patients (n = 202) | Sjögren’s Dry Eye (n = 101) | Non-Sjögren’s Dry Eye (n = 101) | P Valuea |
|---|---|---|---|---|
| Baseline osmolarity | 305.1±14.4 | 306.1±15.8 | 304.4±13.2 | .06 |
| Final osmolarity | 303.2 ±17.6 | 306.5±12.2 | 301.4±19.6 | .05 |
| Change in osmolarityb | –3.0±19.4 | +.5±17.9 | –4.2±20.2 | - |
| Baseline Schirmer’s | 9.6±9.0 | 8.2±8.9 | 11.9±8.8 | .006 |
| Final Schirmer’s | 11.8±9.9 | 10.6±9.5 | 13.6±10.7 | - |
| Change in Schirmer’sb | +1.9±14.1 | +1.7±15.4 | +2.5±11.7 | - |
| Baseline conjunctival staining | 2.9±2.2 | 3.5±2.2 | 2.4±2.0 | .001 |
| Final conjunctival staining | 1.1±1.6 | 1.6±1.9 | .6±1.2 | < .001 |
| Change in conjunctival staining b | –1.8±2.1 | –2.0±2.2 | –1.7±2.1 | - |
| P < .001 | P < .001 | P < .001 | ||
| Baseline corneal staining | 2.0±1.4 | 2.2±1.4 | 1.9±1.3 | - |
| Final corneal staining | .9±1.1 | 1.0±1.1 | .7±1.0 | .05 |
| Change in corneal stainingg | –1.1±1.6 | –1.1±1.7 | –1.2±1.6 | - |
| P < .001 | P < .001 | P < .001 | ||
| Baseline combined ocular surface staining | 4.5±3.1 | 5.0±3.4 | 4.1±2.8 | .10 |
| Final combined ocular surface staining | 1.8±2.2 | 2.4±2.6 | 1.3±1.6 | .002 |
| Change in combined ocular surface staining | –2.7±3.3 | –2.7±3.6 | –2.8±3.0 | - |
| P < .001 | P < .001 | P < .001 |
Values recorded in mean±standard deviation.
aP values were >.10 unless otherwise indicated.
bChanges in objective dry eye parameters were >.10 unless otherwise indicated.