Table 3.

Unadjusted annualized percent change in retinal layer thicknesses in controls and in MS subtypes

	Unadjusted annualized percent change in retinal layer thickness, mean (95% CI)
	HC (n=132 eyes)	RRMS (n=351 eyes)	PPMS (n=115 eyes)	SPMS (n=247 eyes)
pRNFL	−0.37% (−0.53% to −0.20%)	−0.59% (−0.68% to −0.49%)	−0.69% (−0.86% to −0.53%)	−0.69% (−0.80% to −0.59%)
GCIPL	−0.18% (−0.30% to −0.06%)	−0.37% (−0.44% to −0.31%)	−0.67% (−0.80% to −0.55%)	−0.54% (−0.63% to −0.46%)
INL	−0.20% (−0.27% to −0.13%)	−0.27% (−0.31% to −0.22%)	−0.33% (−0.41% to −0.26%)	−0.38% (−0.42% to −0.33%)
ONL	−0.11% (−0.21% to −0.02%)	−0.17% (−0.23% to −0.12%)	−0.27% (−0.37% to −0.17%)	−0.30% (−0.36% to −0.24%)

HC: healthy controls; RRMS: relapsing remitting multiple sclerosis; PPMS: primary progressive multiple sclerosis; SPMS: secondary progressive multiple sclerosis; CI: confidence intervals; pRNFL: peri-papillary retinal nerve fiber layer; GCIPL: ganglion cell + inner plexiform layer; INL: inner nuclear layer; ONL: outer nuclear layer